Sara Colombetti
Head of Global Department Roche
Seminars
Thursday 11th December 2025
Uncovering the Translational Value of Humanized Mouse Models for T-Cell Engager Development
9:30 am
- Enhancing translational predictability – Explore how humanized mouse systems can capture key pharmacodynamic changes, immune activation patterns, and tumor microenvironment dynamics to better forecast T-cell engager efficacy in patients
- Bridging the gap to clinical outcomes – Discuss how these models inform dose selection, immune trafficking, and safety readouts, while recognizing current limitations in replicating complex human immune biology
- Toward smarter preclinical workflows – Learn strategies to combine humanized in vivo models with patient-derived ex vivo platforms, advancing more predictive translational frameworks that reduce attrition and accelerate clinical success
