Randeep Singh

Randeep is a Senior Research Scientist in Autoimmune and Inflammation Disease Biology at Immunocore, where he serves as research lead for a pre-clinical autoimmune programme. Within this programme, they have developed a CD1a-targeted PD-1 agonist designed to localise immune inhibition to the skin. Randeep’s role combines scientific strategy, experimental prioritisation, and cross-functional coordination to generate decision-enabling evidence packages to support programme progression. His work centres on T-cell biology, primary human-cell assay development, and lead candidate characterisation, with an emphasis on interrogating mechanisms of action.
Randeep has nearly a decade of experience in translational human immunology and inflammatory skin biology. Before joining Immunocore in 2021, he was a postdoctoral researcher in Professor Graham Ogg’s laboratory at the MRC Weatherall Institute of Molecular Medicine, University of Oxford. His research investigated the role of endogenous lipases in CD1a-mediated lipid antigen recognition by T cells in inflammatory skin disease, with a focus on psoriasis.
During his PhD research, Randeep examined how the early growth response transcription factors Egr2 and Egr3 regulate T-cell effector function, specifically investigating their role in controlling T-bet-mediated interferon-gamma production. Across these roles, his work has focused on deciphering fundamental T-cell biology to drive the discovery and development of targeted therapies for autoimmune and inflammatory diseases.