Mireille Vankemmelbeke
Seminars
Thursday 10th December 2026
Refining T Cell Bispecifics by Incorporating Competitive Binding & Affinity Tuning Strategies to Improve Solid Tumour Therapy
10:00 am
- Exploring novel approaches including competitive binding strategies and presaturation with blocking antibodies to improve tumour penetration and widen the therapeutic window
- Multi-effector engagement for enduring tumour control
- Leveraging affinity tuning to exploit differential antigen expression, using lower-affinity binders to selectively target tumours with higher antigen density
