Next–Generation Approaches To Overcome Key Liabilities In T-Cell Engager Development & Enhancing Translation with Humanized Mice Models
- “Smart” engagers for precision oncology – Conditionally-activated platforms that restrict T cell engagement to the tumor, solving critical on-target/off-tumor toxicities and widening the therapeutic window.
- Leveraging costimulation – Providing a safe costimulatory signal without autonomous T cell activation to enhance strength & durability of anti-tumor responses
- Enhancing translational predictability – Explore how humanized mouse models can capture key pharmacodynamic changes, immune activation patterns, and tumor microenvironment dynamics to better forecast T cell engager efficacy in patients