Multifunctional Biomolecular Assemblies: Nucleic Acid & Chemical Conjugation Modular Designs
- Description of a multifunctional platform using albumin as a scaffold for assembly of functionalised nucleic acid modules or chemical conjugation for combinatorial T-cell engager designs
- The incorporation of albumin sequences with different FcRn affinity for programmable pharmacokinetics of T-cell engagers
- Discussing how these synthetic combinatorial formats approaches may accelerate therapeutic prototyping and allow flexible integration of targeting and effector domains compared to traditional protein engineering