MP0632: A Conditional Switch DARPin T Cell Engager with CD2 Co Stimulation Driving Selective Targeting of MSLN & EpCAM Tumours
- MP0632 redefines precision T-cell engagement through logic-gated design to address limited immunotherapy efficacy in high unmet need solid tumours
- Dual targeting of MSLN and EpCAM enables selective activation in dual-positive tumour cells with no signs of peripheral T-cell activation, reducing off-tumour effects and supporting expansion to other co-expressing indications
- CD2 co-stimulation sustains T-cell function and potency, driving durable, localised responses with an improved therapeutic window and favourable safety profile