Achieving sustained, long-lasting responses remains one of the most pressing challenges in T-cell engager development, with resistance and T-cell exhaustion frequently limiting clinical durability. This workshop will explore

how these mechanisms arise and how the field can move towards long-term efficacy.

• Delving into resistance mechanisms, including antigen loss, tumour heterogeneity and checkpoint upregulation, to predict and prevent patient relapse
• Uncovering how continuous T-cell activation leads to exhaustion and identifying practical approaches from dosing holidays to combination strategies for restoring T-cell fitness
• Assessing the potential of T-cell fitness biomarkers in predicting responsiveness, stratifying patients, and guiding treatment regimens