AND-Gated Switch-DARPins T-Cell Engager with Co-Stimulation for Safer, More Durable Anti-Tumour Immunity
- Selective Tumour Targeting: Conditional Switch-DARPin selectively induces T cell cytotoxicity against dual-TAA expressing tumour cells, sparing single-antigenexpressing cells
- Enhanced T Cell Function: CD2 co-engagement promotes sustained T cell proliferation and prevents T cells dysfunction, supporting durable antitumour responses
- Favorable Safety Profile: In vivo and human whole blood studies show significant tumour regression with minimal cytokine release, highlighting the potential for safe, logic-gated immune activation